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  1. #1
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    Game changing research on PEG MGF & IGF-1?

    New Method of using PEG-MGF & IGF-1 LR3



    Proliferation and Differentiation. What do these two words mean, how do these processes promote muscle growth, and how do we optimize them through the use of PEG-MGF and IGF-1? Please allow me to break this down into its most simple form. MGF is the hormone responsible for expanding our pool of stem cells. The expansion of these cells is what's known as proliferation. Proliferation is the 1st step in the process of forming new muscle cells. Once these stems cells have recieved the message to proliferate through the actions of MGF, what type of cells they become, whether muscle or otherwise, depends on the message they later recieve from other hormones.

    IGF-1 is what's know as a differentiator. Differentiation is the process responsible for turning immature stem cells into a defined cell type. When a stem cell is exposed to the actions of IGF-1, the cell type created is a muscle cell. However, it is very important to note that each of these processes must take place at the correct time. If one process is begun before the other has finished its work, either the entire process is short-circuited, or partial results are achieved. When a muscle(s) is exposed to stress (such as weight training), it's first response is to produce localized MGF. MGF is produced only in the muscle, not in the liver like GH mediated IGF-1 production. After training, It is vital that MGF be allowed to fully perform its function of proliferation before IGF-1 is introduced into the system. Otherwise, the inhibitory actions IGF1 will immediately halt the proliferation process and reduce the total number of stem cells available for differentiation into muscle cells. In other words, introducing IGF-1 at the wrong time will limit our rate of muscle growth.

    In the past, the typical maner of administering PEG MGF and IGF-1 would be to use 200-300 mg of PEG-MGF immediately post-workout 2X weekly, followed by an injection of IGF-1 the other 5 days per week. In principle this theory is sound, as the PEG-MGF will expand the number of available stem cells, which can then subsequently be differentiated by IGF-1 the following day. However, there are 3 significant problems with this method of use. For one, since PEG-MGF is typically injected only 2 X per week, the BB'r is usually going to choose to inject it after training the bodyparts he most wants to improve, but what happens if he also trains a bodypart on the days he adminsters IGF-1? Being that IGF-1 is typicallly administered on the days PEG-MGF isn't (which is usually 5 days per week), it is highly likley that the BB'r is going to be training on at least some of the days he adminsters IGF-1. That means that on those days, the growth process involving these growth factors will be short-circuited, due to the inhibitory actions of exogenous IGF-1, and the end result will be less than optimal muscle growth.

    The second issue which arises due to the current pattern of use, is that by using PEG-MGF on non-consecutive days 2X per week, the proliferation process will always be cut short due to the constant interloping of exogenous IGF-1. Because of this, the number of available stem cell will never grow very large and the potential for differenetiation will remain limited. The 3rd issue is in regards to PEG-MGF dosing....it is too light. It is now proposed that using 2 mg per week is much closer to the ideal dosage than the commonly prescribed 400 mg per week. If we use prior research as a gauage for determining proper dosing, it would point to our current dosing guidelines as being inadequate. It is a certainty that higher dosages of PEG-MGF are necessary in order to maximize stem cell proliferation. Although user experiences in this dosing range are currently minimal, what has been witnessed does appear to confirm this. In addition, the proposal is scientifically sound.

    Now that I have explained the logic for why the older methods of administration are believed to be flawed in their approach, I will go over how to implement the new method of administration. The PEG-MGF molecule is always used over standard MGF, as MGF has a very short active life, being only minutes in length, while PEG-MGF will stay active for days. This enables the PEG version to deliver a much more pronounced effect. It is also important to remember that the PEG attachment does not alter the effects of the MGF molecule. The PEG attachment acts purely to extend its duration of action. As for what form of IGF-1 should be chosen, I believe IGF-1 LR3 is the superior choice only because of its greatly extended active life, which is about 24 hours in length. DES IGF-1 is a very potent form of IGF-1, being about 4X as potent as IGF-1 LR3 on a mcg basis, but its active life is only about 20 minutes. So, unless one was willing and able to administer DES many times per day, LR3 remains the better option for whole-body growth. DES is superior for site enhancment and will also deliver systematic benefits, but when it comes to a single daily injection, DES cannot trump LR3 when it comes to its whole-body benefits.

    In contrast to most other injectable drugs, PEG-MGF cannot be administered with a singular inject. Several micro-injects must be used because even though PEG-MGF is systematic in its effects, the injected muscle will still recieve a greater amount of benefit. Why? While both steroid esters and the PEG attachemnt serve primarily to extend the active life of the steroid, there are critical differences between the two. With esterfied AAS, the ester must first be cleaved from the steroid before it is able to attach to the AR and cause muscle growth. This is why esterfied steroids do not cause site growth (although some users think they do due to the inflammation and subsqeuent swelling which occurs), as the steroid will already have entered circulation and become systemtaic prior to the ester being cleaved from the steroid molecule. However, unlike AAS, the PEG portion of the drug does not need to be cleaved off before it is able to attach to its receptor site and deliver its message. Also unlike AAS, the MGF molecule (whether it is MGF or PEG-MGF) communicates through cell to cell interaction. Once the PEG-MGF comes in contact with a muscle cell (such as during an injection), the affected muscle cell will relay the same signal to the adjoining muscle cells. More so, this signal will eventually stop being passed along to adjoining cells, making a single inject unsuitable for treating the entire muscle.

    Another characteristic of PEG-MGF, which plays a role in the way it is administered, is the fact that it causes a disproportionate degree of muscle growth in the injected muscle, compared to the rest of the body. However, with PEG-MGF being systematic in nature, one might ask why this happens, being that the compound will eventually spread around to the entire body anyway. This is a question I would have to research, so I cannot answer it right now. Still, I speculate that there may be 3 reasons for this. For one, the injected muscle is directly exposed to the entire amount of the drug on a first come basis. Two, the compound will immediately begin attaching to receptor sites as soon as it is injected, likley using up a substantial portion of the drug before it has a chance to become systematic. Three, due to the micro-injection technique, which is explained below, the entire muscle is exposed to the actions of the drug in large quantities.

    Below I will lay out the micro-injection technique. It is a pain in the ass to be sure, but due to the use of 30-31g. insulin needles, this process is made much more tolerable. The micro-injection process involves injecting a small portion of the drug into multiple locations within the same muscle. In the case of smaller bodyparts, this can be as many as 14-16 injections, split bi-laterally. In larger bodyparts, 20 injections split bilaterally is more appropriate. Remember, MGF communicates its actions cell to cell, so this micro-injection technique must be incorporated into one's protocol if optimal results are desired. Using a small amount of injections will drastically limit the amount ofuscle cells which are exposed to the actions of the MGF...and a single injection will severely limit the drug's ability to turn on stem cell proliferation. Now, before anyone is turned away by the sheer volume of injections, it should be noted that this only needs to be performed twice weekly. In addition, the use of 30-31g. 1/2 inch insulin pins reduces scar tissue build-up to less than what would be experienced with just a couple injections using a 22 g. needle. the pain factor is almost a non-issue, as it should be near painless. Lastly, this only needs to be performed for 4 weeks, after which point MGF injections cease and are then followed by a single sub-q IGF-1 LR3 injection per day for the next 4 weeks. It is up to the individual if they want to repeat the program after its conclusion.


    Here is an example of how one might target their chest with this program:

    Weeks 1-4
    Day #1 (post-workout): Inject 1 mg of PEG-MGF into the pecs. Split this 1 mg up into twenty 50 mcg injections and place 10 injects on the right side of the chest, followed by 10 injects in the left side of the chest. Make sure each injection is placed fairly evenly apart. Use a 30-31g. 1/2 inch syringe.

    Day #2 (about 3-4 days after day 1): Same as above.


    Weeks 5-8
    Days 1-28: IGF-1 LR3 @ 100 mcg once daily.
    Last edited by Mike Arnold; 02-07-2012 at 06:12 PM.

  2. #2
    M&S Veteran JayT's Avatar
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    Great read! Really interested in the "continued"....

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    Member Sgordy243's Avatar
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    I am very uneducated on peptide's I've been reading a lot on them but they are kinda confusing. But I am interested I just have a lot more digging to do before I try them out. Great read mike I appreciate you sharing your knowledge with us

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    Great post mike.

    Please continue!

    Can u also cover the correct injection methods of peg mgf ie several shots per muscle belly ? Is it sterile/safe to use 1 slin pin per 3 shots or would one use several pins per muscle to keep sterile?

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    Great post mike.

    Please continue!

    Can u also cover the correct injection methods of peg mgf ie several shots per muscle belly ? Is it sterile/safe to use 1 slin pin per 3 shots or would one use several pins per muscle to keep sterile?

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    Nice write up!.

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    lookin forward to the further development of this article. SUBSCRIBED!

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    Quote Originally Posted by 06tekos View Post
    lookin forward to the further development of this article. SUBSCRIBED!
    Actually Arnold should be subscribed , he always bring original / well researched information.

    Thank you, Mike!

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    M&S Veteran JayT's Avatar
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    MA, usually I reconstitute my MGF with 1 ml / 2000 mcg, so I get 10iu = 200 mcg. Inorder to get the desired 50 mcg per inj. that would be 2.5iu per site, very very small, so will using 2 ml / 2000 mcg affect the pep? If not that would give an easier 5iu per site for the inj., easier to read. What do you think?

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    Quote Originally Posted by JayT View Post
    MA, usually I reconstitute my MGF with 1 ml / 2000 mcg, so I get 10iu = 200 mcg. Inorder to get the desired 50 mcg per inj. that would be 2.5iu per site, very very small, so will using 2 ml / 2000 mcg affect the pep? If not that would give an easier 5iu per site for the inj., easier to read. What do you think?
    Use the 2 ml...you can use as much water as you want. It doesn't harm the peptide.

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    Quote Originally Posted by JayT View Post
    MA, usually I reconstitute my MGF with 1 ml / 2000 mcg, so I get 10iu = 200 mcg. Inorder to get the desired 50 mcg per inj. that would be 2.5iu per site, very very small, so will using 2 ml / 2000 mcg affect the pep? If not that would give an easier 5iu per site for the inj., easier to read. What do you think?
    Remember, if you do this, you cannot use ANY GH/GH peps or IGF-1 duting the 1st month when you're using the PEG-MGF. If you do, you will short-circuit the proliferation process, waste your MGF, and get reduced results.

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    Very good writeup. This article also goes through IGF and its variants in a very scientific manner. http://suppversity.blogspot.com/2012...ilding_29.html. I'm not in any way affiliated with that site, just found it one day, its a treasure chest of information.

    Here's the different topics covered in the article:

    1. IGF-1 and its Splice Variants MGF, IGF-IEa & Co - Are the growths hormones master regulators of muscle growth or just a bunch of cogs in the wheel of skeletal muscle hypertrophy?

    2. IGF-1, TNF-α, IL-15 & Co and the Emerging Role of an Auto-/Endocrine-Immune Axis in Skeletal Muscle Hypertrophy - How does inflammation factor in, is it beneficial or detrimental?

    3. Zoning in on "The Big T" - Does testosterone (alone) build muscle?

    4. Quantifying "The Big T" - Do increases of testosterone, which are well within the physiological range matter?

    5. Understanding the "Big T" - How does testosterone work? What is its effect on stem cells and how come it makes you leaner?

    6. Estrogen, Friend or Foe of Skeletal Muscle Hypertrophy? - Which role does estrogen play and why could you SERM away your growth potential, when you (ab-)use tamoxifen or potent aromatase inhibitors?

    7. Dihydrotestosterone (DHT), The All Things Male Hormone - Will it make you bigger, stronger and faster or just balder, fatter and unhealthier?

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    M&S Veteran JayT's Avatar
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    Quote Originally Posted by Mike Arnold View Post
    Remember, if you do this, you cannot use ANY GH/GH peps or IGF-1 duting the 1st month when you're using the PEG-MGF. If you do, you will short-circuit the proliferation process, waste your MGF, and get reduced results.
    I think this would be an excellent log opportunity! Lot of great stuff with little down side or bad side effects! Great idea MA!

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    I agree jay! I think after my gh pep run I'll switch to peg mgf then the igf lr3 regime. Sounds awesome! Whole body igf boosts plus building lagging body parts.......epic win!

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    M&S Veteran JayT's Avatar
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    Quote Originally Posted by Mike Arnold View Post
    Remember, if you do this, you cannot use ANY GH/GH peps or IGF-1 duting the 1st month when you're using the PEG-MGF. If you do, you will short-circuit the proliferation process, waste your MGF, and get reduced results.
    MA, does this include GHRP 2 and CJC 1295? (been using them 3xd for a month or so) If so the CJC takes about 28 days to clear the system effectively from what I gather, so ....? What do you think?

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    Quote Originally Posted by JayT View Post
    MA, does this include GHRP 2 and CJC 1295? (been using them 3xd for a month or so) If so the CJC takes about 28 days to clear the system effectively from what I gather, so ....? What do you think?
    Yes, it includes any GH peptide.

    What type of CJC-1295 were you using...the one "with" or "without" dac? The one without dac only stays active a few hours. The with dac version is about 1 week, but if you don't use any GHRP-s with it, you don't have to worry about it, as CJC-1295 with dac by itself doesn't release much Gh at all. In other words, you would not have to wait to start the MGF & IGF-1 protocol if you wanted to.

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    Mike when you get to weeks 5-8 with igf-1 lr3 when is the best time of day to do the lr3? Also is it ok to test and deca while on the peg mgf? Thanks

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    Bump

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    M&S Veteran Adrenolin's Avatar
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    I'd like to try this. Has anyone else tried it with any success? Was thinking to try it on the brachialis and the long head (outer) of the biceps, or maybe rear delts.

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