Apex Peptides
Results 1 to 10 of 10
  1. #1
    M&S Veteran Rreign's Avatar
    Join Date
    Jun 2018
    Posts
    550
    Rep Power
    16

    Interesting theory on Prolactin and B Vitamins

    I copied and pasted this from an article that was posted in another forum but it's a good read and a good theory for those of us running 19nor compounds.

    Vitamin B6 is a surprisingly effective prolactin inhibitor that is extremely cheap and safe: One human study showed a single 300mg dosage of B6 exerts ***8216;a hypothalamic dopaminergic effect***8217; which causes a ***8216;significant decrease of plasma prolactin***8217;(1); Another found that 300mg of B6 taken twice a day by 10 normal women lowered prolactin levels and slightly but significantly raised growth hormone levels. The authors concluded: ***8216;The effect of vitamin B6 is likely to be mediated by dopaminergic receptors at hypothalamic level***8217;(2); Another study found B6 to significantly reduce ***8216;opioids-induced hyperprolactinemia***8217;(3); This study on men found that ***8216;Pyridoxine (B6) suppresses the rise in prolactin and increases the rise in growth hormone induced by exercise***8217;(4); And a study on male rats found that, ***8216;Pyridoxine hydrochloride significantly suppressed the chlorpromazine-induced prolactin rise (p less than 0.01). However, the suppression was significantly less than that produced by bromocriptine (p less than 0.01)***8217;(5). [Note: The last study shows B6 to be less effective than Bromocriptine as a prolactin inhibitor but, stacked with vitamin e and SAM-e, along with some of the secondary prolactin inhibitors I list at the bottom of the page, effects comparable to bromocriprine can be achieved.] The vast majority of people receive the very low RDA for vitamin b6 (2mg) from their diets so this isn***8217;t an issue of correcting a deficiency. It appears, instead, that extra vitamin B6, i.e. around 600mg spread throughout the day, acts in a drug like manner to lower prolactin levels. It***8217;s important to realize, however, that the RDA for B6 is set extremely low and many people benefit from getting considerably more than 2mg per day of this vitamin. Vitamin B6 in high doses has been shown in studies to: - Reduce high blood pressure. - Improve mood and combat depression - Lower blood sugar levels in diabetics - Act as an effective calcium channel blocker A very high dose of B6 may act as a prolactin inhibitor in certain people by correcting a functional deficiency of this vitamin that can occur. Inflammation in the body can create a greater demand for B6 so bodybuilders and athletes may require more of this vitamin. Pyrolurics, according to Dr. Carl Pfeiffer and Dr. Abram Hoffer, have an increased need for zinc and B6. People suffering from this illness create abnormally high levels of chemicals called kryptopyrroles, which bind to zinc and B6 in the body, creating deficiencies in both. The standard treatment for pyroluria is high dose zinc and B6 supplementation, typically 50-150 mg and 250-1500 mg respectively (way above the RDA for both).

    Side effects: High doses of B6 taken for many months can cause nerve problems such as tingling in the fingers and numbness in the toes (peripheral neuropathy); B6 can also worsen sleep quality in some people and cause vivid dreams. Fortunately, these problems completely resolve once B6 supplementation is stopped and, since it is water soluble, this won***8217;t take too long.

    Ways around these side effects: One way to avoid the ***8216;finger tingling***8217; that high dose B6 can cause is to take the activated form of B6 called Pyridoxal-5-Phosphate (P5P) - the activated form of B6 does not cause these nerve issues. In fact, the reason that high dose B6 causes nerve problems is that the body can***8217;t always process very high B6 doses properly and this creates a deficiency of the active form of B6, P5P.

    Recommended dosage: To lower prolactin levels I would recommend you take 50 to 200mg of P5P a day, in divided doses. If you want to take regular B6, which as I've mentioned can sometimes cause minor side effects, take 300 to 1000 mg per day in divided doses. Read the label before you buy B6 because the Pyridoxine Hydrochloride type of B6 (in most supplements) has been shown to be a prolactin inhibitor but Pyridoxal hydrochloride has been shown to be ineffective at lowering prolactin (6) ***8211; make sure you buy the right type

  2. #2
    Member
    Join Date
    Jul 2018
    Posts
    89
    Rep Power
    3
    Very interesting. I usually take a stress b complex with my multi everyday

  3. #3
    Member BigBaldBeardGuy's Avatar
    Join Date
    Jul 2018
    Posts
    23
    Rep Power
    2
    Iíve followed the articles on B6 as a prolactin inhibitor and thatís what I use when running 19-Nors. It seems to be effective so far but I still have a stash of caber just in case. It never hurts to be prepared.



  4. #4
    M&S Veteran Rreign's Avatar
    Join Date
    Jun 2018
    Posts
    550
    Rep Power
    16
    Quote Originally Posted by BigBaldBeardGuy View Post
    I’ve followed the articles on B6 as a prolactin inhibitor and that’s what I use when running 19-Nors. It seems to be effective so far but I still have a stash of caber just in case. It never hurts to be prepared.
    Same here man. I try to do as much as I can without using a pharmaceutical AI or prolactin inhibitor but I always have Aromasin and Caber on hand.

  5. #5
    Member
    Join Date
    Jul 2018
    Posts
    89
    Rep Power
    3
    Quote Originally Posted by BigBaldBeardGuy View Post
    Iíve followed the articles on B6 as a prolactin inhibitor and thatís what I use when running 19-Nors. It seems to be effective so far but I still have a stash of caber just in case. It never hurts to be prepared.
    How much b6 do you need to take for the prolactin inhibition? And is it just b6 or do the other b vitamins play a role as well?

    Just wondering if what I take would be enough or if I would need to take more. I currently take 2 super b complex with breakfast and dinner

  6. #6
    Member BigBaldBeardGuy's Avatar
    Join Date
    Jul 2018
    Posts
    23
    Rep Power
    2
    Quote Originally Posted by Haywire View Post
    How much b6 do you need to take for the prolactin inhibition? And is it just b6 or do the other b vitamins play a role as well?

    Just wondering if what I take would be enough or if I would need to take more. I currently take 2 super b complex with breakfast and dinner
    I take two 100 mg B-6 from NOW in the morning and another two in the evening so 400 mg of B-6 per day (I think you can take 600 mg/fat safely too). Used it during my last Tren cycle where I gradually went from 350 mg/week to 500 mg/week (too high but wanted to see where my upper limit was). I chose the Now brand because it was one where the B-6 is from pyridoxine HCL. Again, allows have caber or prami on hand just in case. Just might never need to use it.

    Prolactin production occurs when estrogen is high too so the other part of the preventative equation is to either run low test during 19-nor cycles or make sure your estrogen is under control with a good AI.



  7. #7
    M&S Veteran Rreign's Avatar
    Join Date
    Jun 2018
    Posts
    550
    Rep Power
    16
    Quote Originally Posted by BigBaldBeardGuy View Post
    I take two 100 mg B-6 from NOW in the morning and another two in the evening so 400 mg of B-6 per day (I think you can take 600 mg/fat safely too). Used it during my last Tren cycle where I gradually went from 350 mg/week to 500 mg/week (too high but wanted to see where my upper limit was). I chose the Now brand because it was one where the B-6 is from pyridoxine HCL. Again, allows have caber or prami on hand just in case. Just might never need to use it.

    Prolactin production occurs when estrogen is high too so the other part of the preventative equation is to either run low test during 19-nor cycles or make sure your estrogen is under control with a good AI.
    Yep you pretty much summed it all up nicely lol. I also use NOW brand. Amazon always has great deals with it.

  8. #8
    Member
    Join Date
    Jul 2018
    Posts
    89
    Rep Power
    3
    Oh yeahmy super b complex only has 20mg of b6 a serving, that's way too low to try and get 400mg/ed, I'd be all cracked out from the other b vitamins lol. I also like now brand for most things, but the bulk suppliments from Amazon (all raws from China) are pretty good too and usually much cheaper

  9. #9
    M&S Veteran 'SizeMatters''s Avatar
    Join Date
    Oct 2015
    Location
    In your Mom's backyard, cleaning her Pool...!
    Posts
    1,319
    Rep Power
    65
    Quote Originally Posted by Haywire View Post
    Oh yeahmy super b complex only has 20mg of b6 a serving, that's way too low to try and get 400mg/ed, I'd be all cracked out from the other b vitamins lol. I also like now brand for most things, but the bulk suppliments from Amazon (all raws from China) are pretty good too and usually much cheaper
    https://purebulk.com/pyridoxine-hcl-powder/

    'Size'
    Don't ask the Question, If your 'NOT ' prepared to
    Hear the answer.......!,

    I "Don't" sugar coat shit....!
    I'm 'not' Willy Wonka....!

  10. #10
    Member
    Join Date
    Jul 2018
    Posts
    89
    Rep Power
    3
    Quote Originally Posted by 'SizeMatters' View Post
    Nice!

Similar Threads

  1. Prolactin Gyno vs Estrogen Gyno
    By dietmtndew7 in forum On Cycle Support / Post Cycle Therapy
    Replies: 25
    Last Post: 07-01-2016, 12:52 AM
  2. Replies: 9
    Last Post: 10-03-2015, 12:19 AM
  3. Prolactin Inhibitors
    By Xupack in forum Anabolic Steroids and PED's
    Replies: 9
    Last Post: 08-07-2011, 10:43 PM
  4. interesting..
    By trunkmonkey37 in forum Anabolic Steroids and PED's
    Replies: 4
    Last Post: 12-16-2010, 02:51 AM
  5. An interesting read on synthetic Testosterone
    By MMA777 in forum Anabolic Steroids and PED's
    Replies: 14
    Last Post: 12-07-2010, 03:53 AM

Bookmarks

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •